When it comes to protecting your new lawn from invasive weeds—especially during seeding—Mesotrione is a go-to solution for both DIYers and lawn care pros. This unique, professional-grade herbicide offers targeted control that’s safe for new grass but tough on weeds. Here’s what you need to know about using Mesotrione to keep your lawn healthy and weed-free, especially during those critical early weeks.
What Is Mesotrione?
Mesotrione is a selective herbicide (the active ingredient in products like Tenacity® and MESO 4SC Select) designed for both pre- and post-emergent weed control in turfgrass. It works by inhibiting photosynthesis in susceptible weeds, causing them to turn white and die off—without harming most desirable grass types when used as directed. Mesotrione is available as a liquid concentrate, making it easy for DIYers to apply with precision during seeding or renovation projects.
What Weeds Does Mesotrione Control?
Mesotrione is highly effective against:
- Grassy Weeds: Crabgrass, goosegrass, barnyardgrass, annual bluegrass, creeping bentgrass.
- Broadleaf Weeds: Dandelion, clover, chickweed, henbit, foxtail, nutsedge, and more.
This makes Mesotrione a versatile choice for both specialty situations (like seeding) and for tackling tough, hard-to-control weeds in cool-season and select warm-season lawns.
When Should You Apply Mesotrione?
Timing is key for effective weed control:
- Pre-Emergent During Seeding: Apply Mesotrione at the same time you seed your lawn. It prevents weeds from germinating and competing with your new grass, but won’t harm the grass seed itself.
Important: Apply before grass seed germinates—if you wait until after, Mesotrione can harm young grass. - Post-Emergent Applications: If you have leftover product, you can use Mesotrione to control existing weeds like dandelion, clover, and certain weedy grasses. Wait until your new grass has been mowed at least 3–4 times (or 30 days after germination) before applying post-emergent.
- Cool-Season Lawns: (Kentucky Bluegrass, Tall Fescue, Fine Fescue, Ryegrass) — Ideal for fall and spring seeding projects.
- Warm-Season Lawns: (Centipede, Buffalograss) — Labeled for use, but always check the product label for specific grass type restrictions.
Note: Not for use on bentgrass, zoysia, bermuda, or St. Augustine.
How to Apply Mesotrione
- Choose the Right Product: MESO 4SC Select is the generic version of Tenacity, offering the same active ingredient at a great value.
- Mixing: Use the included syringe to measure and dilute Mesotrione with water in a pump or backpack sprayer.
Do not use a hose-end sprayer for this product. - Application Method:
- For pre-emergent use at seeding, apply evenly over the area and water in with ¼ inch of irrigation or rainfall.
- For post-emergent use, add a non-ionic surfactant to help the herbicide stick to weed leaves. No need to water in.
- Application rate: 1 tsp per gallon of water per 1,000 sq ft
- Coverage: One 8 oz bottle covers 1–2 acres.
- Visual Results: Weeds will turn white within 5–7 days and die off in about 3 weeks. Temporary whitening of turfgrass is possible but will fade.
Integrating Mesotrione Into Your Lawn Care Routine
- Seeding Success: Mesotrione is especially valuable during lawn renovation or overseeding, giving your new grass a head start by suppressing weed competition.
- Monitor for Weeds: After establishment, use leftover product for spot treatments on tough weeds.
- Combine with Good Practices: Proper mowing, watering, and fertilization help your lawn recover from weed stress and thrive.
Safety and Environmental Tips
- Keep Children and Pets Off Treated Areas: Until the spray has dried.
- Avoid Drift: Do not spray on windy days or near desirable plants.
- Storage: Store in a cool, dry place away from sunlight and out of reach of children.
- Check Local Regulations: Some products may not be registered for use in all states—verify before applying.
The Bottom Line
Mesotrione is a powerful ally for DIYers, especially during seeding and specialty weed control situations. By understanding when and how to use it, you can give your new lawn the best possible start and keep tough weeds at bay—all with professional-grade results.
Ready to protect your new lawn? Shop the Lawn Care Nut’s Mesotrione MESO 4SC Select Herbicide for seeding and specialty weed control.
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